Travis Research Institute
Psychology Building 325
Fuller Theological Seminary
180 N. Oakland Ave.
Pasadena, CA 91101-1714
External Collaborative Organizations
California Institute of Technology
International Research Consortium on the Corpus Callosum and Cerebral Connectivity (IRC5)
The Brain Recovery Project
The Human Brain and Cognition Laboratory (HBCL) studies the cognitive and psychosocial impact of congenital and acquired disruption of connectivity and cerebral interactivity in disorders such as agenesis of the corpus callosum and hemispherectomy. The cognitive and social abilities that are studied in persons with these disorders include: general intelligence, basic academic skill, memory, language, executive functioning, visual-spatial processing, problem-solving, mental processing speed, personality, emotion, social inference, social problem-solving, creativity, and adaptive skills. Through comprehensive assessment of mental and social skills, our research is providing patients, families, and physicians with critical information about the consequences of hemispheric disconnection and hemispherectomy, which can inform efforts toward remediation and intervention.
COGNITIVE AND PSYCHOSOCIAL DEFICITS IN AGENESIS OF THE CORPUS CALLOSUM
Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum – the large connective pathway between the right and left hemispheres of the brain. Because the disorder can only be firmly diagnosed by neuroimaging, it has a short research history. Over the past 20+ years the members of Dr. Brown’s lab have played a major role in understanding the consequences of this disorder for cognitive and social functioning.
As a result of this large ongoing research project it has been found that the basic syndrome involves (1) Reduced interhemispheric transfer of sensory-motor information; (2) Reduced cognitive processing speed; and (3) Deficits in complex reasoning and novel problem-solving. These core deficits are expressed as mild to moderate deficiencies across many domains of cognitive, behavioral, and social functioning.
PUBLICATIONS (WITH LINKS):
Brown, W. S. & Paul, L. K. (2019). The neuropsychological syndrome of agenesis of the corpus callosum. Journal of the International Neuropsychological Society. 1-7. doi: https://doi.org/10.1017/S135561771800111X
Young, C.M., Folsom, R.C., Paul, L.K., Su, J., Mangum, R.W., & Brown, W.S. (2019). Awareness of consequences in agenesis of the corpus callosum: semantic analysis of responses. Neuropsychology.
Anderson, L.B., Paul, L.K. & Brown, W.S. (2017). Emotional intelligence in agenesis of the corpus callosum. Arch Clin Neuropsychol. May 1;32(3):267-279.
Paul, L.K., Erickson, R.L., Hartman, J.A. & Brown, W.S. (2016). Learning and memory in individuals with agenesis of the corpus callosum. Neuropsychologia, 86, 183-192. doi:10.1016/j.neuropsychologia.2016.04.013.
Rehmel, J.L., Brown, W.S., & Paul, L.K. (2016). Proverb comprehension in individuals with agenesis of the corpus callosum. Brain Lang. 160, 21-29. http://dx.doi.org/10.1016/j.bandl.2016.07.001.
Bridgman, M. W., Brown, W. S., Spezio, M. L., Leonard, M. K., Adolphs, R., & Paul, L. K. (2014). Facial emotion recognition in agenesis of the corpus callosum. Journal of Neurodevelopmental Disorders, 6(32). doi: 10.1186/1866-1955-6-32.
Erickson RL, Paul LK, Brown WS. (2014). Verbal learning and memory in agenesis of the corpus callosum. Neuropsychologia. 2014 Jul;60:121-30. PubMed PMID: 24933663. doi: 10.1016/j.neuropsychologia.2014.06.003
Brown WS, Anderson LB, Symington MF, Paul LK. (2012). Decision-making in individuals with agenesis of the corpus callosum: expectancy-valence in the Iowa Gambling Task. Arch Clin Neuropsychol. 2012 Aug;27(5):532-44. doi: 10.1093/arclin/acs052
Marco EJ, Harrell KM, Brown WS, Hill SS, Jeremy RJ, et al. (2012). Processing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum. J Int Neuropsychol Soc. 2012 May;18(3):521-9. PubMed PMID: 22390821; PubMed Central PMCID: PMC3605885.
Symington, S. H., Paul, L. K., Symington, M. F., Ono, M., & Brown, W. S. (2010). Social cognition in individuals with agenesis of the corpus callosum. Social Neuroscience, 5(3), 296-308. doi: 10.1080/17470910903462419
Turk, A. A., Brown, W. S., Symington, M., & Paul, L. K. (2010). Social narratives in agenesis of the corpus callosum: linguistic analysis of the Thematic Apperception Test. Neuropsychologia, 48(1), 43-50. doi: 10.1016/j.neuropsychologia.2009.08.009
Mueller KL, Marion SD, Paul LK, Brown WS. (2009). Bimanual motor coordination in agenesis of the corpus callosum. Behav Neurosci. 2009 Oct;123(5):1000-11. PubMed PMID: 19824766
Badaruddin, D. H., Andrews, G. L,. Bolte, S., Schilmoeller, K. J., Schilmoeller, G., Paul, L. K., & Brown, W. S. (2007). Social and behavioral problems of children with agenesis of the corpus callosum. Child Psychiatry Hum Dev, 38(4), 287-302. doi: 10.1007/s10578-007-0065-6
Paul, L. K., Brown, W. S., Adolphs, R., Tyszka, J. M., Richards, L. J., Mukherjee, P., & Sherr, E. H. (2007). Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nature Reviews Neuroscience, 8(4), 287-299. doi: 10.1038/nrn2107
Paul, L. K., Lautzenhiser, A., Brown, W. S., Hart, A., Neumann, D., Spezio, M., & Adolphs, R. (2006). Emotional arousal in agenesis of the corpus callosum. International Journal of Psychophysiology, 61(1), 47-56. doi: 10.1016/j.ijpsycho.2005.10.017
Brown, W. S., Paul, L. K., Symington, M., & Dietrich, R. (2005). Comprehension of humor in primary agenesis of the corpus callosum. Neuropsychologia, 43(6), 906-916. https://doi.org/10.1016/j.bandl.2004.09.003
Brown, W. S., Symingtion, M., VanLancker-Sidtis, D., Dietrich, R., & Paul, L. K. (2005). Paralinguistic processing in children with callosal agenesis: emergence of neurolinguistic deficits. Brain and Language, 93(2), 135-139. https://doi.org/10.1016/j.bandl.2004.09.003
Paul, L. K., Schieffer, B., Brown, W. S. (2004). Social processing deficits in agenesis of the corpus callosum: narratives from the Thematic Appreciation Test. Archives of Clinical Neuropsychology, 19(2), 215-225. https://doi.org/10.1016/S0887-6177(03)00024-6
Paul, L. K., Van Lancker-Sidtis, D., Schieffer, B., Dietrich, R., Brown, W. S. (2003). Communicative deficits in agenesis of the corpus callosum: nonliteral language and affective prosody. Brain and Language, 85(2), 313-324. https://doi.org/10.1016/S0093-934X(03)00062-2
Brown, W.S. (2003) Clinical neuropsychological assessment of callosal dysfunction: Multiple sclerosis and dyslexia. In E. Zaidel, and M. Iacoboni (Eds.). The Parallel Brain: The Cognitive Neuroscience of the Corpus Callosum. Cambridge: MIT Press. https://psycnet.apa.org/record/2003-06310-016
Hines, R. J., Paul, L. K., Brown, W. S. (2002). Spatial attention in agenesis of the corpus callosum: shifting attention between visual fields. Neuropsychologia, 40(11), 1804-1814. https://doi.org/10.1016/S0028-3932(02)00032-5
Brown, W. S., Thrasher, E. D., & Paul, L. K. (2001). Interhemispheric Stroop effects in partial and complete agenesis of the corpus callosum. Journal of the International Neuropsychological Society, 7(3), 302-311. doi:10.1017/S1355617701733048
Brown W.S. and Paul L.K., (2000) Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence. Cognitive Neuropsychiatry. 5, 135-157. doi: 10.1080/135468000395781
Brown, WS, Jeeves, MA, Dietrich, R., and Burnison, DS. (1999) Bilateral field advantage and evoked potential interhemispheric transmission in commissurotomy and callosal agenesis. Neuropsychologia, 37, 1154-1180. https://doi.org/10.1016/S0028-3932(99)00011-1
Brown, W.S., Bjerke, M.D., & Galbraith, G.C. (1998) Interhemispheric transfer in normals and acallosals: Latency adjusted evoked potential averaging. Cortex, 34, 677-692. https://doi.org/10.1016/S0010-9452(08)70772-X
ADULT COGNITIVE AND PSYCHOSOCIAL outcomes FROM CHILDHOOD HEMISPHERECTOMY
Hemispherectomy involves surgical removal of an entire cerebral hemisphere. This procedure is typically done in children as a last-resort treatment for intractable seizures. Despite the fact that this surgical procedure has been used as a treatment for epilepsy in children since the 1980s, there is very little published research on the long-term impact of this treatment on the neuropsychological functioning of these children when they reach adulthood.
Since 2015 the HBCL has been studying neuropsychological and psychosocial functioning in adults who had childhood hemispherectomy. While these studies are still underway, it is clear that what is being discovered will help inform patients, families, and physicians about the outcome of the treatment. There are also important general scientific questions about brain function and intelligence to be investigated by comparing the outcomes of AgCC and hemispherectomy.
Cory Harrison, Paul Figueroa, Amanda Panos, Lynn K. Paul, & Warren S. Brown, “Adult Behavior and Executive Functioning Following Childhood Hemispherectomy: Self- Report.” Meeting of the International Neuropsychological Society, Washington D.C., Feb. 2018.
Amanda Panos, Paul Figueroa, Justin Miller, Lynn K. Paul, & Warren S. Brown, “Adult Adaptive Functioning Following Childhood Hemispherectomy.” Meeting of the International Neuropsychological Society, Washington D.C., Feb. 2018.
Paul A. Figueroa, Amanda Panos, Karissa A. Burnett, Lynn K. Paul, & Warren S. Brown, “Self-Perception of Social Norms and Empathy in Adults After Childhood Right Hemispherectomy.” Meeting of the International Neuropsychological Society, Washington D.C., Feb. 2018.
Kristina M. Moncrieffe, Lynn K. Paul & Warren S. Brown, “Verbal and Performance IQ in Left and Right Hemispherectomy Patients.” Meeting of the American Psychological Society, San Francisco, June 2018.
Krista J. Cowan, Cory E. Kowalski, Kristina Moncrieffe, Amanda Panos, Lynn Paul, & Warren S. Brown, “Emotional Functioning Following Childhood Hemispherectomy.” Meeting of the American Psychological Society, Washington D.C., May 2019.
Mitchell Spezzaferri, Cory E. Kowalski, Kristina Moncrieffe, Amanda Panos, Lynn Paul, & Warren S. Brown, “Social Cognition in Individuals with Hemispherectomy.” Meeting of the American Psychological Society, Washington D.C., May 2019.
Faculty and Principal investigator
Professor of Psychology and Director of Travis Research Institute
BA, POINT LOMA NAZARENE UNIVERSITY
MA, PHD, UNIVERSITY OF SOUTHERN CALIFORNIA
POSTDOCTORAL SCHOLAR, UCLA BRAIN RESEARCH INSTITUTE
Cory Kowalski, M.A. Cory is pursuing the Ph.D. in Clinical Psychology. She is involved in research aimed at better understanding executive functioning deficits following childhood hemispherectomy
Katie Mukai. Katie is pursuing the Ph.D. in Clinical Psychology, in the Neuropsychology track. Her current research is focused on exploring executive function outcomes in adults who have undergone childhood hemispherectomy to treat intractable seizures.
Krista Cowan, M.A. Krista is pursuing the Psy.D. in Clinical Psychology at Fuller, in the Neuropsychology track. Her current research focuses on understanding emotional intelligence and emotional functioning in adults who underwent childhood hemispherectomy due to intractable seizures.
Kristina Moncrieffe, M.A. Kristina is pursuing the Psy.D. in Clinical Psychology. Her current research interests involve analyzing patterns of intellectual and academic deficits and strengths in adult individuals with hemispherectomies.
Ashley Vaillancourt, M.A. Ashley is a Ph.D. Candidate in Clinical Psychology. Ashley has been actively researching the psychosocial outcomes of agenesis of the corpus callosum and utilizes these findings as a moderator at the biennial National Organization of Disorders of the Corpus Callosum conference.
Doori Jeong, M.A. Doori is a Ph.D. Candidate in Clinical Psychology, in the Neuropsychology track. Doori has over five years of experience working in the cognitive neuroscience and pathology research lab. She has worked in a rehabilitation hospital and in neuropsychology assessment in private practice. She considers it a privilege to help people better understand themselves in order to maximize their strengths and potentials.
Mitchell Spezzaferri, M.A. Mitchell is pursuing the PhD in Clinical Psychology in the Neuropsychology track. He is interested in research involving the social-cognitive/emotional functioning of individuals who underwent hemispherectomy. He's also investigating the neurobiology of how we make moral decisions.
Judy Su, M.A.
Paul Figueroa, M.A.
External Collaborative Organizations (external links)
International Research Consortium on the Corpus Callosum and Cerebral Connectivity (IRC5)
The Brain Recovery Project
CalTech Emotion and Cognition Lab
National Organization for Disorders of the Corpus Callosum